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EAE susceptibility in FVB mice
Author(s) -
Baker Anne Marie,
Grekova Maria C.,
Richert John R.
Publication year - 2000
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/1097-4547(20000715)61:2<140::aid-jnr4>3.0.co;2-x
Subject(s) - encephalomyelitis , genetically modified mouse , transgene , in vivo , myelin basic protein , experimental autoimmune encephalomyelitis , immunology , freund's adjuvant , biology , adjuvant , myelin , gene , multiple sclerosis , central nervous system , neuroscience , genetics
The in vivo study of immunologic mechanisms in experimental allergic encephalomyelitis (EAE) requires, in some instances, the use of transgenic mice. As FVB mice represent a strain whose fertilized ova possess a relatively large pronucleus, this is a preferred strain in which to generate mice that are transgenic for a variety of genes. An important issue, then, is whether the FVB background supports the development of EAE. We report here that relapsing EAE is easily and reproducibly induced in FVB mice with whole myelin basic protein in complete Freund's adjuvant. J. Neurosci. Res. 61:140–145, 2000. © 2000 Wiley‐Liss, Inc.