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Outcome after treatment for papillary thyroid cancer
Author(s) -
Lin JenDer,
Hsieh ShengHwu,
Chang HungYu,
Huang ChaoChun,
Chao TzuChieh
Publication year - 2001
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/1097-0347(200102)23:2<140::aid-hed1009>3.0.co;2-h
Subject(s) - medicine , stage (stratigraphy) , thyroid carcinoma , papillary thyroid cancer , thyroid cancer , thyroglobulin , retrospective cohort study , thyroid , gastroenterology , cancer , carcinoma , distant metastasis , metastasis , urology , surgery , paleontology , biology
Background To evaluate the results of treatment and the prognostic variables of papillary thyroid carcinoma patients after long‐term follow‐up. Patients and Methods Retrospective review of 1373 thyroid cancer patients. Of the 1016 papillary thyroid cancer patients, 394 patients received follow‐up for more than 5 years, including 305 women (mean age, 38.4 ± 13.7 years) and 89 men (mean age, 44.0 ± 13.4 years). Of these papillary thyroid carcinoma patients, 227, 76, 68, and 23 patients were categorized in clinical stages I, II, III, and IV, respectively, at the time of diagnosis. Results After treatment, 36 (9.1%) patients died. Only 23 (5.8%) of them died of papillary thyroid carcinoma. The 1‐, 5‐, 10‐, and 20‐year survival rates were 0.980, 0.951, 0.901, and 0.731. Mortality factors of the papillary thyroid carcinoma patients related to age, gender, tumor size, and postoperative serum thyroglobulin (Tg) levels. Twenty‐four patients progressed from clinical stages I, II, and III to stage IV during the follow‐up period. Of these 24 patients, 12 died during the follow‐up period. In this study, age, gender, 131 I accumulated dose, postoperative serum Tg levels, and the survival rate were demonstrated to be statistically significant between the patients in early stage and advanced stage groups after treatment. Conclusion Twenty‐four of the 47 papillary thyroid cancer patients with distant metastases were diagnosed during the follow‐up period. This study suggests that distant metastasis may occur at a serum Tg level of 2.3 ng/mL with thyroxine replacement. Postoperative long‐term close follow‐up of these patients is recommended. © 2001 John Wiley & Sons, Inc. Head Neck 23: 140–146, 2001.