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Evolution of precancerous laryngeal lesions: A clinicopathologic study with long‐term follow‐up on 259 patients
Author(s) -
Gallo Andrea,
de Vincentiis Marco,
Della Rocca Carlo,
Moi Rossana,
Simonelli Marilia,
Minni Antonio,
Shaha Ashok R.
Publication year - 2001
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/1097-0347(200101)23:1<42::aid-hed7>3.0.co;2-1
Subject(s) - carcinoma in situ , dysplasia , medicine , intraepithelial neoplasia , carcinoma , biopsy , incidence (geometry) , gastroenterology , dermatology , surgery , cancer , prostate , physics , optics
Background A wide spectrum of lesions ranging from dysplasia to in situ carcinoma have to be considered when dealing with laryngeal precancerous conditions. Recently the concept of laryngeal intraepithelial neoplasia (LIN) was introduced. Methods A series of 259 consecutive cases of laryngeal keratosis was studied from 1976 to 1994. All patients entered the study after microlaryngoscopy and biopsy. Histologic diagnoses were subdivided into keratosis without dysplasia (KWD), with mild dysplasia (LIN 1), with moderate dysplasia (LIN 2), and with severe dysplasia or carcinoma in situ (LIN 3). The follow‐up period ranged from 15 months to 19 years (mean, 101 months). Results KWD had the best prognosis with the lowest recurrence rate (12.5%) after stripping of laryngeal mucous membrane. The recurrence rate after stripping was higher for LIN 1 (25%) and LIN 2 cases (68.7%). The recurrence rate after CO 2 laser cordectomy was 16.6% for LIN 2 and 18.7% for LIN 3. The incidence of progression to infiltrative carcinoma was 4.19% for KWD, 7.14% for LIN 1, 21.42% for LIN 2, and 9.37% for LIN 3. Conclusions KWD and LIN 1 can be successfully treated by stripping the mucous membrane, close follow‐up, and a change in smoking habits. On the contrary, LIN 2 and LIN 3 need a more aggressive therapeutical approach. © 2000 John Wiley & Sons, Inc. 23: 42–47, 2001.