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Genetic polymorphisms in head and neck cancer risk
Author(s) -
McWilliams Jeffrey E.,
Evans Adam J.,
Beer Tomasz M.,
Andersen Peter E.,
Cohen James I.,
Everts Edwin C.,
Henner William David
Publication year - 2000
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/1097-0347(200009)22:6<609::aid-hed10>3.0.co;2-l
Subject(s) - head and neck cancer , medicine , genotyping , head and neck squamous cell carcinoma , oncology , population , logistic regression , genotype , case control study , cancer , gene , genetics , biology , environmental health
Objective To assess whether genetic polymorphisms implicated as risk factors for other tobacco‐associated malignancies are associated with altered risk of head and neck squamous cell carcinoma. Design Case‐control study. Subjects One hundred sixty patients with head and neck squamous cell carcinoma recruited from a university‐based head and neck oncology clinic and 149 population‐based controls. Methods Genotyping of the CYP1A1 (Ile462Val), GSTM1 (null), GSTP1 (Ile105Val), GSTT1 (null), and P53 (Arg72Pro) genes was performed by polymerase chain reaction–based techniques on DNA prepared from peripheral blood. In addition, a questionnaire was used to collect demographic information from each subject. Results Cases were significantly older ( p < .0001) and had significantly greater tobacco use ( p < .0001) and were more likely to be male ( p < .0001) than were control subjects, thus confirming known risk factors for this disease. When cases and controls were compared by simple chi‐square analysis, only the frequency of CYP1A1 (Ile462Val) polymorphism was significantly different between cases and controls (OR = .42; 95% CI = .18–.99; p < .04). However, with a logistic regression model to control for known risk factors, we were unable to demonstrate a significant association with head and neck cancer for any of the polymorphisms tested, including CYP1A1. Conclusions This population fails to identify a relationship between the above‐mentioned polymorphisms and head and neck cancer. © 2000 John Wiley & Sons, Inc. Head Neck 22: 609–617, 2000.