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Subglottic stenosis secondary to extramedullary hematopoiesis in a patient with postpolycythemia myeloid metaplasia
Author(s) -
Barnes Elizabeth A.,
Seikaly Hadi,
Puttagunta Lakshmi,
Coupland Robert W.,
Jha Naresh
Publication year - 2000
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/1097-0347(200007)22:4<435::aid-hed17>3.0.co;2-5
Subject(s) - extramedullary hematopoiesis , medicine , radiation therapy , myeloid , metaplasia , myelofibrosis , radiology , stenosis , surgery , pathology , bone marrow , haematopoiesis , genetics , stem cell , biology
Background Extramedullary hematopoiesis (EMH) is known to occur in myeloproliferative disorders and hemoglobinopathies and is usually seen in the spleen and liver. Methods We report the first case of EMH causing subglottic stenosis in a woman with postpolycythemia myeloid metaplasia (PPMM). A tracheotomy was performed to maintain the airway and local radiotherapy was given. Results Two months after the radiotherapy was completed laryngoscopy showed an unobstructed airway with no evidence of disease, and the patient was successfully decanulated. Magnetic resonance imaging 8 months after radiotherapy confirmed the absence of local disease. Conclusion Consideration should be given to EMH as a possible cause of airway obstruction in the differential diagnosis of a patient with a history of PPMM. © 2000 Wiley & Son, Inc. Head Neck 22: 435–438, 2000.