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Cytological aspects of melanotic variant of medullary thyroid carcinoma
Author(s) -
de Lima Marcus Aurelho,
Dias Medeiros Juliana,
Rodrigues da Cunha Liane,
de Cássia Caldas Pessôa Rita,
Silveira Tavares Fernanda,
de Fátima Borges Maria,
Marinho Eurípedes Oliveira
Publication year - 2001
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/1097-0339(200103)24:3<206::aid-dc1042>3.0.co;2-h
Subject(s) - medicine , calcitonin , pathology , thyroid carcinoma , thyroid , carcinoembryonic antigen , medullary carcinoma , medullary cavity , fine needle aspiration , chromogranin a , carcinoma , lymph node , immunohistochemistry , cancer , biopsy
We had the opportunity to examine a case of fine‐needle aspiration (FNA) of a melanotic variant of medullary thyroid carcinoma (MTC) in a 20‐yr‐old man. The patient presented a single node, hardened and mobile upon deglutition, in the right lobe of the thyroid, for 9 mo, without symptoms of glandular dysfunction. Calcitonin (138 pg/ml), urinary calcium (177 mg/dl), and the carcinoembryonic antigen (341 ng/ml) were increased. The nodular aspirate, drawn by FNA, was represented by pleomorphic cells, with frequent intranuclear cytoplasmic inclusions, sometimes bi‐ or multinucleated, with abundant, finely granular cytoplasm, sometimes containing a brown pigment resembling melanin. An immunohistochemical study using monoclonal antibodies (Dako Corp., Carpinteria, CA) showed that the neoplastic cells were intensely and diffusely positive for calcitonin and chromogranin, and focally positive for HMB45. In view of these findings, the case was characterized as a melanotic variant of medullary carcinoma, a rare type of neoplasia, but having a prognosis similar to the classical variant of MTC. Diagn. Cytopathol. 2001;24:206–208. © 2001 Wiley‐Liss, Inc.