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Fine‐needle sampling of primary neuroendocrine carcinomas of salivary glands: Cytohistological correlations and clinical analysis
Author(s) -
Klijanienko Jerzy,
Lagacé Réal,
Servois Vincent,
Lussier Christian,
ElNaggar Adel K.,
Vielh Philippe
Publication year - 2001
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/1097-0339(200103)24:3<163::aid-dc1034>3.0.co;2-i
Subject(s) - pathology , chromogranin a , medicine , multinucleate , salivary gland , eosinophilic , immunostaining , keratin , acinic cell carcinoma , cytoplasm , immunohistochemistry , biology , mucoepidermoid carcinoma , microbiology and biotechnology
Fine‐needle samplings of nine examples of primary neuroendocrine carcinoma of salivary glands were evaluated for their cytologic characteristics and were correlated with the corresponding histological sections. Consistent cytological findings were dispersed or loose clusters of poorly differentiated small‐ to intermediate‐sized cells and occasional smudged nuclei. Mild to moderate nuclear pleomorphism, scant or absent cytoplasm, and nuclear molding were also observed. Rosette‐like patterns and multinucleated cells were occasionally seen. Immunostaining of one recent case showed positivity for chromogranin and keratin. The differential diagnosis of primary and metastatic tumors with neuroendocrine features of the salivary glands is discussed. Diagn. Cytopathol. 2001;24:163–166. © 2001 Wiley‐Liss, Inc.