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Gastrointestinal stromal tumor with skeinoid fibers of the ileum
Author(s) -
Hirokawa Mitsuyoshi,
Tashiro Takashi,
Horiguchi Hidehisa,
Wakatsuki Shingo,
Kanahara Takuo,
Monobe Yasumasa,
Sano Toshiaki
Publication year - 2000
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/1097-0339(200010)23:4<266::aid-dc10>3.0.co;2-m
Subject(s) - gist , hyaline , pathology , cd34 , stromal cell , stromal tumor , periodic acid–schiff stain , eosinophilic , medicine , trichrome stain , trichrome , cytology , stain , anatomy , immunohistochemistry , staining , biology , h&e stain , microbiology and biotechnology , stem cell
Gastrointestinal stromal tumor (GIST) is not uncommon among gastrointestinal nonepithelial tumors, but there are few reports describing the cytologic findings. We report a case of GIST with skeinoid fibers in scrape cytology preparation. The patient was a 53‐year‐old man with a tumor in the small intestine. Scrape preparations from the cut surface of the resected tumor revealed cellular material composed of spindle cells showing loose clusters or single cells. The nuclei were spindled, elongated or cigar‐shaped, and relatively uniform. The cytoplasm was fragile and demonstrated a finely fibrillar material. Dense hyaline materials with irregular outline were observed within the loose clusters composed of the tumor cells. The hyaline materials were also observed in the background. Histologic preparation showed spindle cells arranged in a fascicular or storiform pattern. Most eosinophilic globules were distributed between the tumor cells. The globules were positive in periodic acid‐Schiff reaction, and were stained blue with Masson's trichrome stain. Immunohistochemically, the tumor cells were strongly and diffusely positive for c‐kit, focally and weakly positive for α‐smooth muscle actin, and negative for CD34 and S‐100 protein. We emphasize that skeinoid fibers are characteristic of GIST arising in the small intestine, and their presence predicts a good prognosis, even in malignant GIST. Diagn. Cytopathol. 2000;23:266–268. © 2000 Wiley‐Liss, Inc.