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A selenide linker for “traceless” solid‐phase organic synthesis
Author(s) -
Li Zhengong,
Kulkarni Bheemashankar A.,
Ganesan A.
Publication year - 2000
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/1097-0290(2000)71:2<104::aid-bit1000>3.0.co;2-7
Subject(s) - selenide , diselenide , halide , chemistry , ether , linker , alkyl , electrophile , alcohol , organic chemistry , selenium , combinatorial chemistry , polymer chemistry , catalysis , computer science , operating system
4‐Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid‐phase resins. The polymer‐bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides. © 2001 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 71:104–106, 2000/2001.