Premium
Crystal structure of a depsipeptide, Boc–(Leu–Leu–Lac) 3 –Leu–Leu–OEt
Author(s) -
Ohyama Takafumi,
Oku Hiroyuki,
Yoshida Masaru,
Katakai Ryoichi
Publication year - 2001
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/1097-0282(200106)58:7<636::aid-bip1036>3.0.co;2-u
Subject(s) - depsipeptide , chemistry , residue (chemistry) , amino acid residue , stereochemistry , peptide , peptide sequence , organic chemistry , biochemistry , gene
A sequential polydepsipeptide, Boc–(Leu–Leu–Lac) 3 –Leu–Leu–OEt ( 1 ) (Lac = L ‐lactic acid residue) has been synthesized by the segment condensation method. The sequential unit of 1 , –Leu–Leu–Lac–, is consisted of two amino acid residues and one hydroxy acid residue. X‐ray diffraction measurement with an imaging plate detector and a direct‐methods procedure of Shake‐and‐Bake successfully revealed the crystal structure of 1 . In the solid state, the 11‐mer depsipeptide, 1 , have clear α‐helical conformation even with the three ester linkages. © 2001 John Wiley & Sons, Inc. Biopolymers 58: 636–642, 2001