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NMR interaction studies of aromatic guanyl hydrazones with micelles: Model for mechanism of action of cationic antibiotics
Author(s) -
Borges Márcia Narcizo,
FigueroaVillar José Daniel
Publication year - 2000
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/1097-0282(2001)62:1<9::aid-bip20>3.0.co;2-f
Subject(s) - chemistry , micelle , cationic polymerization , bromide , hydrophobic effect , mechanism of action , combinatorial chemistry , relaxation (psychology) , membrane , hydrogen bond , stereochemistry , computational chemistry , organic chemistry , aqueous solution , molecule , biochemistry , in vitro , psychology , social psychology
Interaction studies using hydrogen NMR spin–lattice relaxation time measurements of a series of five antiparasitic guanyl hydrazones with SDS and cetyl trimethylammonium bromide micelles are used as a simple model for the interaction of these compounds with the cell membrane of Trypanosoma cruzi . The results show that the activity of the compounds is related to their capacity to selectively interact with anionic micelles, which reinforces the hypothesis that the mechanism of action of these compounds is related to their selective interaction with the negatively charged parasite membrane. © 2000 John Wiley & Sons, Inc. Biopolymers (Biospectroscopy) 62: 9–14, 2001