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Chemiluminescent method for determination of tetracycline, chlortetracycline, minocycline, doxycycline, and demeclocycline
Author(s) -
Marczyński Sławomir
Publication year - 2000
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/1097-0282(2000)57:6<365::aid-bip60>3.0.co;2-r
Subject(s) - minocycline , chemistry , doxycycline , chlortetracycline , tetracycline , chemiluminescence , oxytetracycline , chromatography , tetracycline antibiotics , antibiotics , biochemistry
A chemiluminescent method is described for the determination of tetracycline, chlortetracycline, minocycline, doxycycline, and demeclocycline. The method is based on the photon counting technique and the spline functions approximation. The simple formula S = b + Ax 2 is proposed for the observed dependency of the integrated number of countings S on the concentration x of a given antibiotic. The correlation between S and the half‐life of a drug in the human body is proved. © 2000 John Wiley & Sons, Inc. Biopolymers (Biospectroscopy) 57: 365–372, 2000