Premium
Incorporation of artificial receptors into a protein/peptide surface: A strategy for on/off type of switching of semisynthetic enzymes
Author(s) -
Hamachi Itaru,
Watanabe Junichi,
Eboshi Ryoji,
Hiraoka Takashi,
Shinkai Seiji
Publication year - 2000
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/1097-0282(2000)55:6<459::aid-bip1021>3.0.co;2-r
Subject(s) - chemistry , receptor , enzyme , peptide , biochemistry , combinatorial chemistry
Recent developments in new bioorganic methodologies have greatly facilitated the site‐specific incorporation of non‐natural amino acids into the protein framework. It is now desirable for chemists to explore promising concepts based on chemistry for regulation and extension of functions of naturally occurring enzymes using non‐natural molecules, in order to promote the new trends in protein/enzyme engineering. This article demonstrates that the concepts of host–guest (or supramolecular) chemistry, which have been developed over the last few decades, provide powerful tools for the artificial control of the functions of native proteins and enzymes. © 2001 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 55: 459–468, 2000