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Structure and regulation of opioid receptors
Author(s) -
Chaturvedi Kirti,
Christoffers Keith H.,
Singh Kamalendra,
Howells Richard D.
Publication year - 2000
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/1097-0282(2000)55:4<334::aid-bip1006>3.0.co;2-s
Subject(s) - chemistry , opioid , receptor , opioid peptide , g protein coupled receptor , opioid receptor , ligand (biochemistry) , agonist , rhodopsin , biochemistry , retinal
Significant advances have been made in understanding the structure, function, and regulation of opioid receptors and endogenous opioid peptides since their discovery approximately 25 years ago. This review summarizes recent studies aimed at identifying key amino acids that confer ligand selectivity to the opioid receptors and that are critical constituents of the ligand binding sites. A molecular model of the δ receptor based on the crystal structure of rhodopsin is presented. Agonist‐induced down regulation of opioid receptors is discussed, highlighting recent evidence for the involvement of the ubiquitin/proteasome system in this process. © 2001 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 55: 334–346, 2000