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The human interferon α species and receptors
Author(s) -
Pestka Sidney
Publication year - 2000
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/1097-0282(2000)55:4<254::aid-bip1001>3.0.co;2-1
Subject(s) - chemistry , receptor , interferon , computational biology , biochemistry , virology , biology
Interferon (IFN) was approved by the U.S. Food and Drug Administration on June 5, 1986. As the first biotherapeutic approved, IFN‐α paved the way for development of many other cytokines and growth factors. Nevertheless, we have just touched the surface of understanding the multitude of human IFNs. This paper reviews the history of the purification of human leukocyte IFN and key aspects of our current state of knowledge of human interferon α genes, proteins, and receptors. © 2001 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 55: 254–287, 2000