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Functionalization of peptides and proteins by aldehyde or keto groups
Author(s) -
Melnyk Oleg,
Fehrentz JeanAlain,
Martinez Jean,
GrasMasse Hélène
Publication year - 2000
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/1097-0282(2000)55:2<165::aid-bip50>3.0.co;2-#
Subject(s) - chemistry , surface modification , aldehyde , posttranslational modification , combinatorial chemistry , organic chemistry , enzyme , catalysis
The functionalization of peptides and proteins by aldehyde or keto groups has become the subject of intensive research since the discovery of the inhibition properties of peptide aldehydes and the advent of protein engineering. The first part of this review focuses upon the tremendous efforts devoted to the solid‐phase synthesis of peptide aldehydes as protease inhibitors. The second part describes the utility of the aldehyde or keto functionalities for the site‐specific modification of peptides or proteins. © 2000 John Wiley & Sons, Inc. Biopoly 55: 165–186, 2000