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Lung cancer risk in iron and steel foundry workers: A nested case control study in Asturias, Spain
Author(s) -
Rodríguez Valentín,
Tardón Adonina,
Kogevinas Manolis,
Prieto Carlos S.,
Cueto Antonio,
García Mario,
Menéndez Ignacio A.,
Zaplana Juán
Publication year - 2000
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/1097-0274(200012)38:6<644::aid-ajim5>3.0.co;2-m
Subject(s) - medicine , lung cancer , environmental health , risk factor , asbestos , record linkage , incidence (geometry) , case control study , logistic regression , cancer , mesothelioma , demography , surgery , population , metallurgy , pathology , materials science , physics , sociology , optics
Background Workers of iron and steel foundries have a high lung cancer risk but the findings on specific processes associated with this risk are inconsistent. We examined the risk of lung cancer among workers in the main industrial processes of a large iron and steel foundry in Asturias, Spain. Methods We conducted a nested case‐control study comprised of 144 male lung cancer cases and 558 controls, selected from a study base of about 24,400 workers employed in the industry between 1952 and 1995. Cases were identified through linkage of industry records with those of two cancer registries. Controls were selected through industry records using incidence density sampling, were matched to cases by age and date of birth and had to be alive and without lung cancer at the time of selection. Smoking history was obtained through company medical records. Unconditional logistic regression was applied and all ORs were adjusted for age and tobacco consumption. Results Workers were, on an average, heavy smokers and a very strong relation was observed for smoking (OR for “ever smoker” = 32.4). Workers having ever been employed in the blast furnace had an excess lung cancer risk (OR = 2.55, 95% CI 1.25–5.21) compared to a reference group of workers not employed in metal producing departments. A similar excess was observed for workers having as their longest held job employment in the blast furnace. A two‐fold risk was also observed for workers in the main foundry. For subgroups of workers, tobacco smoking appeared to be an important positive or negative confounder. Conclusions In this large Spanish foundry, a high risk was observed for workers employed in departments with high exposure to crystalline silica, PAHs, and various other carcinogenic chemicals. Although comparisons were made between workers of the same industry, smoking habits differed and adjustment by smoking modified considerably the risk estimates. Am. J. Ind. Med. 38:644–650, 2000. © 2000 Wiley‐Liss, Inc.