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Cloning genes whose levels of expression are altered by metals: Implications for human health research
Author(s) -
Rossman Toby G.
Publication year - 2000
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/1097-0274(200009)38:3<335::aid-ajim14>3.0.co;2-h
Subject(s) - gene , gene expression , cloning (programming) , dna microarray , medicine , genetics , toxicogenomics , gene expression profiling , regulation of gene expression , bioinformatics , computational biology , microbiology and biotechnology , biology , computer science , programming language
When cells are exposed to toxicants, changes in gene expression ensue. To date, there is little information on gene expression changes induced by metals in mammalian cells. The basic methods for identifying altered gene expression of both a temporary and a permanent nature are outlined, with examples drawn mostly from what is known about metal‐induced changes in gene expression. The application of this information in the development of new biomarkers of exposure and effect, in identifying individuals with altered susceptibility to metal compounds, and in the choice of genes for microarrays is discussed. Am. J. Ind. Med. 38:335–339, 2000. © 2000 Wiley‐Liss, Inc.