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Separation of nicotine metabolites by capillary zone electrophoresis and capillary zone electrophoresis/mass spectrometry
Author(s) -
Palmer M. E.,
Smith R. F.,
Chambers K.,
Tetler L. W.
Publication year - 2001
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/1097-0231(20010215)15:3<224::aid-rcm213>3.0.co;2-z
Subject(s) - chemistry , capillary electrophoresis , chromatography , capillary electrophoresis–mass spectrometry , mass spectrometry , analyte , tandem mass spectrometry , nicotine , isobaric process , electrophoresis , electrospray ionization , neuroscience , biology , thermodynamics , physics
The use of capillary zone electrophoresis (CZE) and capillary zone electrophoresis/mass spectrometry (CZE/MS) has been demonstrated, in principle, for the separation of nicotine and nicotine metabolites. The buffer system developed for separation and detection by CZE/UV was modified for use in CZE/MS analysis. Several of the metabolites are isobaric and tandem mass spectrometric (MS/MS) techniques have been used to differentiate such analytes. Copyright © 2001 John Wiley & Sons, Ltd.