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Application of a non‐indexed dual sprayer pneumatically assisted electrospray source to the high throughput quantitation of target compounds in biological fluids
Author(s) -
Hiller D. L.,
Brockman A. H.,
Goulet L.,
Ahmed S.,
Cole R. O.,
Covey T.
Publication year - 2000
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/1097-0231(20001115)14:21<2034::aid-rcm124>3.0.co;2-6
Subject(s) - sprayer , chemistry , chromatography , electrospray , mass spectrometry , throughput , computer science , mechanical engineering , telecommunications , engineering , wireless
The need for increased throughput in the quantitation of target compounds in biological fluids by high performance liquid chromatography/mass spectrometry continues to drive research in this area. This report describes the application of a prototype dual sprayer electrospray source for the quantitative analysis of biological samples. Quantitative performance for 180 compounds in a microsomal stability assay was found to be adequate when compared with a conventional single sprayer measurement. Issues with use of dual sprayers in a routine production environment are discussed. Copyright © 2000 John Wiley & Sons, Ltd.