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Mass spectrometry of Avermectins: structural determination of two new derivatives of Ivermectin B 1a
Author(s) -
Gianelli Luca,
Mellerio Giorgio Giacomo,
Siviero Enrico,
Rossi Alessandro,
Cabri Walter,
Sogli Loris
Publication year - 2000
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/1097-0231(20000730)14:14<1260::aid-rcm20>3.0.co;2-#
Subject(s) - chemistry , ivermectin , mass spectrometry , chromatography , zoology , biology
Fragmentation pathways of Avermectins were studied by electron impact (EI), chemical ionisation (CI), electrospray ionisation (ESI) and by collision experiments. Structure characterisation was obtained using ESI combined with multi‐stage (MS n ) tandem mass spectrometry, analysis of homologues, and effects on fragment masses of H/D exchange. By these approaches the structures of two new derivatives of Avermectins were characterised. Copyright © 2000 John Wiley & Sons, Ltd.