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Mass spectra of some new 3,4‐dihydro‐2[ H ]‐pyridones†
Author(s) -
Acherki H.,
AlvarezIbarra C.,
Gutiérrez M.,
MartinezAlvarez R.,
Quiroga M. L.
Publication year - 2000
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/1097-0231(20000715)14:13<1123::aid-rcm999>3.0.co;2-y
Subject(s) - chemistry , mass spectrum , fragmentation (computing) , electrospray ionization , ion , electron ionization , mass spectrometry , analytical chemistry (journal) , ionization , chemical ionization , reagent , tandem mass spectrometry , spectral line , chromatography , organic chemistry , physics , astronomy , computer science , operating system
Electrospray ionization (ESI) and tandem mass spectrometry (MS/MS) experiments, as well as electronic impact (EI) and chemical ionization (CI) techniques, have been applied to the title compounds 1a–h. The observation of different fragmentation pathways in the three sets of spectra is in accord with different degrees of internal excitation of the investigated precursors. In ESI (methanol as solvent) and CI (methane as reagent gas) spectra, the MH + ion represents the most important peak, while the fragments [M − OH] + and [M − SO] + are either the base peak or a very abundant peak in the EI mass spectra of these compounds. ESI‐MS/MS experiments on the parent ions [MH] + show that the loss of a fragment of 140 Da corresponding to p ‐toluenesulfenic acid is common from all the precursors. As well as competitive pathways, the second generation ions have also been elucidated to allow some observations to be made concerning the relationships between structure type and mass spectrometric characteristics. Copyright © 2000 John Wiley & Sons, Ltd.