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Maternal serum human chorionic gonadotrophin levels in systemic lupus erythematosus and antiphospholipid syndrome
Author(s) -
Maymon Ron,
Cuckle Howard,
Sehmi Indera K.,
Herman Arie,
Sherman Dan
Publication year - 2001
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/1097-0223(200102)21:2<143::aid-pd998>3.0.co;2-b
Subject(s) - medicine , gestation , antiphospholipid syndrome , pregnancy , obstetrics , biology , genetics , thrombosis
Maternal serum human chorionic gonadotrophin (hCG) levels were measured during the second and the third trimesters of pregnancy in patients with either systemic lupus erythematosus (SLE) or primary antiphospholipid syndrome (APS). All results were expressed in multiples of the gestation‐specific normal medians (MoM). The median MoM level in 17 samples from SLE patients was 1.48 compared with 0.79 MoM in 99 controls of similar gestation ( p <0.002, Wilcoxon Rank sum test). In contrast the median MoM level in 19 samples from primary APS patients was only 1.14. These preliminary findings should be further studied to evaluate the implications for Down syndrome screening, detection of SLE cases during pregnancy and the prediction of adverse outcome in SLE gestations. Copyright © 2001 John Wiley & Sons, Ltd.