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Fetal varicella‐herpes zoster syndrome in early pregnancy: ultrasonographic and morphological correlation
Author(s) -
Petignat Patrick,
Vial Yvan,
Laurini Richard,
Hohlfeld Patrick
Publication year - 2001
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/1097-0223(200102)21:2<121::aid-pd996>3.0.co;2-p
Subject(s) - medicine , fetus , autopsy , pathology , pregnancy , serology , immunology , biology , antibody , genetics
We report a case of an intrauterine fetal infection by the varicella‐herpes zoster virus following maternal varicella at 17 weeks' amenorrhea. Prenatal diagnosis of fetal infection was confirmed by serology and fetal damage by ultrasonography. Autopsy of the fetus showed multiorgan manifestation with disseminated foci of necrosis and microcalcifications, encephalitis and unilateral segmental skin scarring with an underlying hypoplastic fixed lower limb. The placenta showed a multifocal chronic villitis with multinucleated giant cells. The lesions included segmental anomalies and multiorgan damage. Copyright © 2001 John Wiley & Sons, Ltd.