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Prenatal diagnosis of agnathia‐holoprosencephaly: three‐dimensional imaging by helical computed tomography
Author(s) -
Ebina Yasuhiko,
Yamada Hideto,
Hirayama Kato Emi,
Tanuma Fumie,
Shimada Shigeki,
Cho Kazutoshi,
Fujimoto Seiichiro
Publication year - 2001
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/1097-0223(200101)21:1<68::aid-pd994>3.0.co;2-3
Subject(s) - holoprosencephaly , medicine , prenatal diagnosis , in utero , computed tomography , radiology , ultrasound , fetus , pregnancy , genetics , biology
We report a case of agnathia‐holoprosencephaly which was prenatally diagnosed based on helical computed tomography (CT) images obtained at 23 weeks of gestation. Ultrasound examination first showed the presence of alobar holoprosencephaly, but the facial structures were not clearly detailed. However, three‐dimensional imaging by helical CT precisely demonstrated the most striking feature of agnathia: absence of the mandible. This technique provided us valuable information that contributed to the in utero diagnosis. In utero helical CT is a useful examination tool for the diagnosis of osteogenic abnormalities. Copyright © 2001 John Wiley & Sons, Ltd.