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The influence of parity and gravidity on first trimester markers of chromosomal abnormality
Author(s) -
Spencer K.,
Ong C. Y. T.,
Liao A. W. J.,
Nicolaides K. H.
Publication year - 2000
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/1097-0223(200010)20:10<792::aid-pd914>3.0.co;2-5
Subject(s) - chromosomal abnormality , parity (physics) , obstetrics , first trimester , abnormality , singleton , fetus , second trimester , gynecology , pregnancy , down syndrome , medicine , biology , karyotype , physics , genetics , chromosome , particle physics , psychiatry , gene
We have studied changes in first trimester fetal nuchal translucency (NT) and maternal serum free β‐hCG and PAPP‐A with gravidity and parity in 3252 singleton pregnancies unaffected by chromosomal abnormality or major pregnancy complications. We have shown that gravidity and parity is associated with a small but progressive decrease in fetal NT and a small but progressive increase in free β‐hCG and PAPP‐A. None of these small changes with increasing gravidity or parity are statistically significant and hence correction for these variables is not necessary when considering first trimester screening for chromosomal abnormalities. Copyright © 2000 John Wiley & Sons, Ltd.