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Second trimester levels of maternal serum inhibin A in pregnancies affected by fetal neural tube defects
Author(s) -
LambertMesserlian Geralyn M.,
Palomaki Glenn E.,
Canick Jacob A.
Publication year - 2000
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/1097-0223(200008)20:8<680::aid-pd889>3.0.co;2-f
Subject(s) - anencephaly , neural tube , spina bifida , gestation , neural tube defect , medicine , obstetrics , fetus , third trimester , prenatal diagnosis , second trimester , pregnancy , biology , embryo , surgery , genetics , microbiology and biotechnology
Inhibin A is effective as a second trimester maternal serum marker for Down syndrome screening. In the present study, inhibin A levels were measured in second trimester maternal serum samples from 28 pregnancies affected with open neural tube defects; 12 associated with open spina bifida and 16 associated with anencephaly. Each measurement was expressed as a multiple of the median (MoM) for control singleton pregnancies ( n =1464) of the same completed week of gestation. Inhibin A levels were not significantly altered in cases of open neural tube defects; the median value was 0.96 MoM in cases of open spina bifida and 1.19 MoM in cases of anencephaly. Therefore, second trimester maternal serum inhibin A levels will not have an impact on prenatal detection of open neural tube defects. Copyright © 2000 John Wiley & Sons, Ltd.