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First trimester maternal serum AFP and total hCG in aneuploidies other than trisomy 21
Author(s) -
Spencer K.,
Heath V.,
Flack N.,
Ong C.,
Nicolaides K. H.
Publication year - 2000
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/1097-0223(200008)20:8<635::aid-pd868>3.0.co;2-u
Subject(s) - trisomy , human chorionic gonadotropin , aneuploidy , down syndrome , gestation , gonadotropin , turner syndrome , alpha fetoprotein , gynecology , pregnancy , medicine , biology , obstetrics , endocrinology , hormone , genetics , chromosome , hepatocellular carcinoma , gene
Total human chorionic gonadotropin (hCG) and alpha‐fetoprotein (AFP) were measured in maternal serum at 10–14 weeks of gestation from 53 pregnancies affected by trisomy 18, 42 cases with trisomy 13, 46 with Turner's syndrome and 13 with other sex aneuploides. The only significant association was the finding of reduced levels of total hCG in cases of trisomy 18 and 13. The association of increased levels of AFP in cases of trisomy 18 with ventral wall defects and the slight increase in AFP in cases of sex chromosomal anomalies other than Turner's syndrome was found. AFP and total hCG are not likely to replace the markers free β‐hCG and PAPP‐A in first trimester screening for chromosomal anomalies. Copyright © 2000 John Wiley & Sons, Ltd.