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The decision to cancel a preimplantation genetic diagnosis cycle
Author(s) -
Santaló J.,
Grossmann M.,
Giménez C.,
Marina F.,
Egozcue J.,
Marina S.,
Vidal F.
Publication year - 2000
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/1097-0223(200007)20:7<564::aid-pd874>3.0.co;2-1
Subject(s) - preimplantation genetic diagnosis , pregnancy , selection (genetic algorithm) , human fertilization , offspring , medicine , gynecology , live birth , genetic diagnosis , obstetrics , in vitro fertilisation , sex selection , oocyte , andrology , biology , computer science , embryo , genetics , gene , machine learning
It has been suggested that a minimum number (six) of cumulus‐oocyte complexes (COCs) should be retrieved for fertilization to offer enough chances to ensure a pregnancy after a preimplantation genetic diagnosis (PGD) procedure. Therefore a decision to cancel a PGD cycle should be adequately weighted to offer the patients the highest chances to obtain a pregnancy. We describe a case where, after retrieving only three COCs suitable for fertilization, a triplet pregnancy was obtained. This case suggests that, although low numbers of COCs can reduce the effectiveness of the PGD procedure, other factors are involved in its final result. Thus, the opportunity of routinely cancelling such cycles should be reconsidered. In addition, this is, to our knowledge, the first case where sex selection was carried out to prevent the birth of carriers of the abnormal gene, and not of affected offspring. Copyright © 2000 John Wiley & Sons, Ltd.