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Over‐expression of wild‐type Rad51 correlates with histological grading of invasive ductal breast cancer
Author(s) -
Maacke Heiko,
Opitz Sven,
Jost Kirsten,
Hamdorf Willem,
Henning Wilhelm,
Krüger Stefan,
Feller Alfred Ch.,
Lopens Antje,
Diedrich Klaus,
Schwinger Eberhard,
Stürzbecher HorstWerner
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/1097-0215(20001215)88:6<907::aid-ijc11>3.0.co;2-4
Subject(s) - grading (engineering) , breast cancer , rad51 , cancer research , biology , suppressor , pathogenesis , cancer , tumor suppressor gene , pathology , oncology , medicine , gene , dna repair , carcinogenesis , genetics , ecology
Breast cancer is a major cause of cancer‐related death in women. BRCA1 tumour‐suppressor function is abolished in sporadic breast cancer by down‐regulation of the protein level. This down‐regulation inversely correlates with tumour grading. BRCA1 is part of a multiprotein complex, which also contains the recombination factor Rad51. Here we describe that in contrast to BRCA1, histological grading of sporadic invasive ductal breast cancer significantly correlates with over‐expression of wild‐type Rad51. These data suggest that in addition to the absence of the tumour‐suppressor protein BRCA1, over‐expression of wild‐type Rad51 also contributes to the pathogenesis of a significant percentage of sporadic breast cancers and that other mechanisms than mutations must be responsible for this altered expression. Int. J. Cancer 88:907–913, 2000. © 2000 Wiley‐Liss, Inc.