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Selective activation of the fatty acid synthesis pathway in human prostate cancer
Author(s) -
Swinnen Johannes V.,
Vanderhoydonc Frank,
Elgamal Abdelaziz A.,
Eelen Marianne,
Vercaeren Inge,
Joniau Steven,
Van Poppel Hein,
Baert Luc,
Goossens Karine,
Heyns Walter,
Verhoeven Guido
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/1097-0215(20001015)88:2<176::aid-ijc5>3.0.co;2-3
Subject(s) - lncap , fatty acid synthase , fatty acid synthesis , prostate cancer , prostate , biology , cancer research , cancer , endocrinology , lipid metabolism , lipogenesis , fatty acid , atp citrate lyase , medicine , enzyme , biochemistry , citrate synthase
A substantial subset of breast, colorectal, ovarian, endometrial and prostatic cancers displays markedly elevated expression of immunohistochemically detectable fatty acid synthase, a feature that has been associated with poor prognosis and that may be exploited in anti‐neoplastic therapy. Here, using an RNA array hybridisation technique complemented by in situ hybridisation, we report that in prostate cancer fatty acid synthase expression is up‐regulated at the mRNA level together with other enzymes of the same metabolic pathway. Contrary to the observations that in many cell systems (including androgen‐stimulated LNCaP prostate cancer cells) fatty acid and cholesterol metabolism are co‐ordinately regulated so as to supply balanced amounts of lipids for membrane biosynthesis, storage or secretion, no changes in the expression of genes involved in cholesterol synthesis were found. These findings point to selective activation of the fatty acid synthesis pathway and suggest a shift in the balance of lipogenic gene expression in a subgroup of prostate cancers. Int. J. Cancer 88:176–179, 2000. © 2000 Wiley‐Liss, Inc.