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Pathologic‐radiologic correlations in screen‐detected ductal carcinoma in situ of the breast: Findings of the Singapore breast screening project
Author(s) -
Tan Puay Hoon,
Ho Juliana T.S.,
Ng Eng Hen,
Chiang Gilbert S.C.,
Low Sze Chuan,
Ng Fook Cheong,
Bay Boon Huat
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/1097-0215(20000820)90:4<231::aid-ijc6>3.0.co;2-u
Subject(s) - comedo , medicine , ductal carcinoma , calcification , mammography , breast cancer , fat necrosis , radiology , carcinoma , mammary gland , pathology , cancer
Mammography detected 34 (25%) cases of ductal carcinoma in situ (DCIS) of the breast out of a total of 135 cancers diagnosed in 28,231 participating women during the Singapore breast screening project. Radiologic findings in these 34 women with DCIS were calcifications only in 25 (74%); mass only in 2 (6%); and mass with calcifications in the remaining 7 (20%) cases. Calcifications were classified mammographically as powderish in 2 (6%), crushed stone‐like in 16 (50%) and casting in 14 (44%) cases. Pathologic assessment revealed 11 (32%) cases with pure comedo, 16 (47%) mixed, 3 (9%) cribriform, 2 (6%) papillary, 1 (3%) micropapillary and 1 (3%) solid patterns. Histologic nuclear grade was low in 6 (18%), intermediate in 9 (26%) and high in 19 (56%). Necrosis was observed in 26 (77%) cases and absent in the rest. Pathologic‐radiologic correlations yielded a significant association between the mammographic and pathologic lesional size, with the degree of agreement improved when there was histologic necrosis. A trend for radiologic crushed stone‐like and casting‐type calcifications to be associated with DCIS with necrosis and of higher nuclear grade was noted. Int. J. Cancer (Radiat. Oncol. Invest.) 90, 231–236 (2000). © 2000 Wiley‐Liss, Inc.