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Malignant melanoma in patients with multiple endocrine neoplasia type 1 and involvement of the MEN1 gene in sporadic melanoma
Author(s) -
Nord Brita,
Platz Anton,
Smoczynski Kristina,
Kytölä Soili,
Robertson Gavin,
Calender Alain,
Murat Arnaud,
Weintraub Dominique,
Burgess John,
Edwards Matthew,
Skogseid Britt,
Owen David,
Lassam Norman,
Hogg David,
Larsson Catharina,
Teh Bin Tean
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/1097-0215(20000815)87:4<463::aid-ijc1>3.0.co;2-8
Subject(s) - loss of heterozygosity , cdkn2a , men1 , multiple endocrine neoplasia , melanoma , germline mutation , cancer research , carcinogenesis , tumor suppressor gene , chromophobe cell , biology , cancer , pathology , medicine , allele , mutation , gene , genetics , carcinoma , clear cell
Multiple endocrine neoplasia type 1 (MEN 1) is a familial cancer syndrome associated primarily with endocrine tumors of the parathyroids, enteropancreas and anterior pituitary. However, tumors of mesenchymal origin such as angiofibroma and collagenoma of the skin have also been associated with the syndrome. This highlights the possibility of an association between MEN 1 and some other types of tumors. Here we report 7 cases of primary malignant melanoma occurring in 7 MEN 1 families, all patients exhibiting classic features of MEN 1. Based on these findings and the previous implication of multiple melanoma tumor suppressor(s) in 11q, including the MEN1 region, we have investigated the involvement of the MEN1 gene in melanoma tumorigenesis. Mutation analysis was performed on a panel of 39 sporadic metastatic melanomas, 13 melanoma cell lines and 20 melanoma families without CDKN2A or CDK4 germline mutations. In addition, 19 sporadic metastatic tumors were screened for loss of heterozygosity (LOH) in 11q13. LOH was detected in 6 tumors (32%), and in 4 of the tumors the pattern of LOH suggested that the deletion included the MEN1 gene locus. A novel somatic nonsense mutation in exon 7 (Q349X) was identified in 1 sporadic tumor which also showed loss of the wild‐type allele. We conclude that the MEN1 gene plays a role in the tumorigenesis of a small subgroup of melanoma. Int. J. Cancer 87:463–467, 2000. © 2000 Wiley‐Liss, Inc.