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Low frequency of HLA‐A*0201 allele in patients with Epstein‐Barr virus‐positive nasal lymphomas with polymorphic reticulosis morphology
Author(s) -
Kanno Hiroyuki,
Kojya Shizuo,
Li Ting,
Ohsawa Masahiko,
Nakatsuka Shinichi,
Miyaguchi Mamoru,
Harabuchi Yasuaki,
Aozasa Katsuyuki
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/1097-0215(20000715)87:2<195::aid-ijc6>3.0.co;2-0
Subject(s) - biology , human leukocyte antigen , ctl* , immunology , epstein–barr virus , population , virus , allele , antigen , virology , gene , cd8 , genetics , medicine , environmental health
Lymphoproliferative diseases of the nasal cavity and paranasal sinuses occur frequently in Asian countries and are histologically categorized as monomorphic ordinary lymphoma and polymorphic reticulosis (PR) with apparent inflammatory cell infiltration. The large atypical cells in PR show natural‐killer cell nature and frequently contain Epstein‐Barr virus (EBV) DNA. Among the EBV genes involved in latent infection, those encoding EBV latent membrane proteins are frequently expressed in PR. Several cytotoxic T‐lymphocyte (CTL) defined epitopes have been mapped to latent membrane proteins restricted with HLA‐A2, ‐A11 or ‐A24 antigens. Thus, the HLA‐A allele may affect the development of PR. To examine this possibility, HLA‐A alleles of 25 patients with EBV + PR were determined with low‐resolution polymerase chain reaction‐based typing using HLA‐A locus sequence‐specific primer combinations. The frequency of HLA‐A alleles including HLA‐A2 and ‐A24 antigens in PR patients was lower than that in the normal Japanese population, but the difference was not significant. Since HLA‐A2‐restricted CTL responses are well delineated at the A2‐subtype level, the A2‐subtype of PR cases with HLA‐A2 antigen was further determined by high‐resolution genetic typing. The frequency of HLA‐A*0201 in PR was significantly lower than in the normal population ( p =0.0314). The HLA‐A*0201‐restricted CTL responses may thus function in vivo to suppress the development of overt lymphoma. Int. J. Cancer 87:195–199, 2000. © 2000 Wiley‐Liss, Inc.