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Microsatellite instability in synchronous gastric carcinomas
Author(s) -
Lee Hye Seung,
Lee Byung Lan,
Kim Sun Hee,
Woo Dong Kyun,
Kim Hee Sung,
Kim Woo Ho
Publication year - 2001
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/1097-0215(200002)9999:9999<::aid-ijc1105>3.0.co;2-p
Subject(s) - microsatellite instability , dna mismatch repair , cancer , carcinogenesis , adenoma , medicine , biology , carcinoma , pathology , gastroenterology , cancer research , colorectal cancer , microsatellite , gene , genetics , allele
Synchronous gastric carcinomas are found in 4% to 10% of all gastric carcinomas, and the tumor multiplicity is believed to be related to genetic predisposition. To investigate the role of mismatch repair error in synchronous gastric carcinomas, we analyzed the microsatellite instability (MSI) status of 101 cancers from 48 gastrectomy specimens and compared them with 149 solitary gastric carcinomas. Multiple synchronous gastric carcinomas are characterized by slightly older age, predominance in males, early stage and lower lymph node metastasis. Among the 48 cases, 8 (18 lesions) were associated with a gastric adenoma (type I) and 40 (83 lesions) were not associated with a gastric adenoma (type II). The MSI + rate was 50% in the type I and 8.4% in the type II synchronous gastric carcinomas ( p < 0.001), while that of solitary gastric carcinomas was 9.4%. In addition, the frameshift mutation rates of the TGF‐βRII, BAX and hMSH3 genes in the type I synchronous carcinomas were higher than those in the type II synchronous carcinomas. These findings indicate that a defect in the mismatch repair system might play a role in the carcinogenesis of a minor subset of multiple gastric carcinomas associated with adenomas. © 2001 Wiley‐Liss, Inc.