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High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases
Author(s) -
Chiappetta Gennaro,
Manfioletti Guidalberto,
Pentimalli Francesca,
Abe Nobutsugu,
Di Bonito Maurizio,
Vento Maria Teresa,
Giuliano Ada,
Fedele Monica,
Viglietto Giuseppe,
Santoro Massimo,
Watanabe Takashi,
Giancotti Vincenzo,
Fusco Alfredo
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/1097-0215(200002)9999:9999<::aid-ijc1033>3.0.co;2-v
Subject(s) - high mobility group , medicine , hyperplasia , cancer research , biology , oncology , pathology , genetics , gene
HMGI(Y) proteins are overexpressed in experimental and human malignancies, including colon, prostate and thyroid carcinomas. To determine at which step of the carcinogenic process HMGI(Y) induction occurs, we analysed the expression of the HMGI(Y) proteins in hyperplastic, preneoplastic and neoplastic tissues of colorectal origin by immunohistochemistry. All the colorectal carcinomas were HMGI(Y)‐positive, whereas no expression was detected in normal colon mucosa tissue. HMGI(Y) expression in adenomas was closely correlated with the degree of cellular atypia. Only 2 of the 18 non‐neoplastic polyps tested were HMGI(Y)‐positive. These data indicate that HMGI(Y) protein induction is associated with the early stages of neoplastic transformation of colon cells and only rarely with colon cell hyperproliferation. © 2001 Wiley‐Liss, Inc.