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Incidence of ovarian cancer among alcoholic women: A cohort study in Sweden
Author(s) -
Lagiou Pagona,
Ye Weimin,
Wedrén Sara,
Ekbom Anders,
Nyrén Olof,
Trichopoulos Dimitrios,
Adami HansOlov
Publication year - 2000
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/1097-0215(200002)9999:9999<::aid-ijc1027>3.0.co;2-k
Subject(s) - ovarian cancer , medicine , incidence (geometry) , etiology , confidence interval , cohort , cancer , gynecology , cohort study , standardized mortality ratio , demography , physics , optics , sociology
Linkage of nationwide databases in Sweden allowed us to evaluate the incidence of ovarian cancer among 36,856 women diagnosed with alcoholism between 1965 and 1994. Mean duration of follow‐up was 9.6 years, for a total of 317,518 person‐years at risk. The expected number of cases of ovarian cancer was calculated by multiplying the number of person‐years by 5‐year age group and calendar year‐specific incidence rates of ovarian cancer in Sweden. The effect measure was the standardized incidence ratio (SIR), with 95% confidence intervals (CIs). Our results indicate an overall deficit of cases of ovarian cancer of about 14% among women with a diagnosis of alcoholism. This deficit is particularly strong and statistically significant among alcoholic women younger than 60 years (SIR = 0.76, 95% CI 0.58–1.00). This deficit is compatible with the reported reduction of gonadotrophin levels among alcoholic women younger than 60 years and with the hypothesis invoking these gonadotrophins in the etiology of ovarian cancer. © 2001 Wiley‐Liss, Inc.