Open AccessEvent‐related fMRI study of response inhibition
Author(s) -
Liddle Peter F.,
Kiehl Kent A.,
Smith Andra M.
Publication year - 2001
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/1097-0193(200102)12:2<100::aid-hbm1007>3.0.co;2-6
Subject(s) - dorsolateral prefrontal cortex , functional magnetic resonance imaging , neuroscience , anterior cingulate cortex , psychology , supplementary motor area , prefrontal cortex , go/no go , primary motor cortex , motor cortex , cerebellum , brain activity and meditation , cingulate cortex , posterior parietal cortex , central nervous system , electroencephalography , cognition , computer science , machine learning , stimulation
Event‐related functional magnetic resonance imaging (erfMRI) was employed to measure the hemodynamic response during a Go/No‐go task in 16 healthy subjects. The task was designed so that Go and No‐go events were equally probable, allowing an unbiased comparison of cerebral activity during these two types of trials. In accordance with prediction, anterior cingulate was active during both the Go and No‐go trials, dorsolateral and ventrolateral prefrontal cortex was more active during the No‐go trials, while primary motor cortex, supplementary motor area, pre‐motor cortex and cerebellum were more active during Go trials. These findings are consistent with the hypothesis that the anterior cingulate cortex is principally engaged in making and monitoring of decisions, while dorsolateral and ventral lateral prefrontal sites play a specific role in response inhibition. Hum. Brain Mapping 12:100–109, 2001. © 2001 Wiley‐Liss, Inc.