Open AccessDetecting bilateral abnormalities with voxel‐based morphometry
Author(s) -
Salmond C.H.,
Ashburner J.,
VarghaKhadem F.,
Gadian D.G.,
Friston K.J.
Publication year - 2000
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/1097-0193(200011)11:3<223::aid-hbm80>3.0.co;2-f
Subject(s) - voxel , neuroscience , brain damage , voxel based morphometry , neuroimaging , psychology , medicine , radiology , magnetic resonance imaging , white matter
In this article we describe a new method, using SPM99, that searches explicitly for bilateral structural abnormalities. Children with bilateral pathology have a poorer prognosis than children with unilateral damage. After brain injury or disease in childhood, it is thought that rescue of function is only possible if the neuronal substrates of that function are preserved and operational in at least one hemisphere [Vargha‐Khadem and Mishkin, 1997]. If this is the case, the detection of bilateral abnormalities would greatly facilitate more accurate prognosis in children with brain injury or developmental disorders. We have therefore developed a technique to detect bilateral abnormalities that uses conjunction analysis with voxel based morphometry. It is illustrated using a group of patients with bilateral hypoxic‐ischaemic damage to the hippocampus. The approach is shown to have enhanced specificity and sensitivity relative to conventional unilateral characterisations. Hum. Brain Mapping 11:223–232, 2000. © 2000 Wiley‐Liss, Inc.