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Temporo‐spatial distribution of endothelial‐monocyte activating polypeptide II, an anti‐angiogenic protein, in the mouse embryo
Author(s) -
Zhang Fangrong,
Schwarz Margaret A.
Publication year - 2000
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/1097-0177(200007)218:3<490::aid-dvdy1005>3.0.co;2-c
Subject(s) - biology , in situ hybridization , embryo , central nervous system , immunohistochemistry , respiratory tract , monocyte , morphogenesis , embryogenesis , messenger rna , microbiology and biotechnology , immunology , anatomy , endocrinology , respiratory system , genetics , gene
We describe the temporo‐spatial distribution of Endothelial‐Monocyte Activating Polypeptide (EMAP) II in order to better understand what role this anti‐angiogenic proteins may play in fetal development. In situ hybridization, immunohistochemistry, and Western analysis were performed on fetal, neonatal, and adult tissue. EMAP II was first detected only within the central nervous system on 9 days postcoitum (dpc). Subsequently, at 11 through 18 dpc, EMAP II expression was detected in the respiratory, central nervous, cardiovascular, urogenital systems, sense organs, and digestive tract. EMAP II mRNA and protein was localized to the epithelium, with its highest expression in neurons, blood vessels, and at sites of epithelial‐mesenchymal interaction. The temporo‐spatial distribution of EMAP II suggests that it could play an important role in morphogenesis of the vertebrate embryo. Dev Dyn 2000;218:490–498. © 2000 Wiley‐Liss, Inc.