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Src family kinase function during early Xenopus development
Author(s) -
Weinstein Daniel C.,
HemmatiBrivanlou Ali
Publication year - 2001
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/1097-0177(2000)9999:9999<1::aid-dvdy1098>3.0.co;2-5
Subject(s) - fgf and mesoderm formation , mesoderm , biology , proto oncogene tyrosine protein kinase src , microbiology and biotechnology , fibroblast growth factor , signal transduction , genetics , gene , embryonic stem cell , receptor
The Src family kinase Laloo functions downstream of the fibroblast growth factor (FGF) receptor, as a component of a signaling pathway required for mesoderm formation. In this study, we first show that Laloo expression can mimic FGF function in a distinct context, suggesting that the Src‐related kinases are general transducers of FGF signaling during development. We then characterize the role of the SH‐PTP2 phosphatase, and of bone morphogenetic protein (BMP)‐pathway signaling, in mesoderm induction by Laloo. Finally, we demonstrate that the mesoderm‐inducing activity of the Src family kinases is not limited to Laloo, indicating a degree of functional overlap between members of this gene family during early vertebrate development. © 2001 Wiley‐Liss, Inc.