Premium
Comparative genomic hybridization of esophageal squamous cell carcinoma
Author(s) -
Yen ChuehChuan,
Chen YannJang,
Chen JungTa,
Hsia JiunYi,
Chen PoMin,
Liu JinHwang,
Fan Frank S.,
Chiou TzeonJye,
Wang WeiShu,
Lin ChiHung
Publication year - 2001
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20011201)92:11<2769::aid-cncr10118>3.0.co;2-m
Subject(s) - medicine , comparative genomic hybridization , esophageal squamous cell carcinoma , basal cell , carcinoma , pathology , oncology , cancer research , genetics , genome , gene , biology
Abstract BACKGROUND Esophageal carcinoma is a major cause of cancer‐related deaths among males in Taiwan. However, to date, the genetic alterations that accompany this lethal disease are not understood. METHODS Chromosomal aberrations of 46 samples of esophageal squamous cell carcinoma (EC‐SCC) were analyzed by comparative genomic hybridization (CGH), and their correlations with pathologic staging and prognosis were analyzed statistically. RESULTS In total, 321 gains and 252 losses were found in 46 tumor samples; thus, the average gains and losses per patient were 6.98 and 5.47, respectively. Frequent gain abnormalities were found on chromosome arms 1q, 2q, 3q, 5p, 7p, 7q, 8q, 11q, 12p, 12q, 14q, 17q, 20q, and Xq. Frequent deletions were found on chromosome arms 1p, 3p, 4p, 5q, 8p, 9p, 9q, 11q, 13q, 16p, 17p, 18q, 19p, and 19q. It was found that deletions of 4p and 13q12–q14 and gain of 5p were significantly correlated with pathologic staging. Losses of 8p22‐pter and 9p also were found more frequently in patients with advanced disease. Gain of 8q24‐qter was seen more frequently in patients with Grade 3 tumors. A univariate analysis found that pathologic staging; gains of 5p and 7q; and deletions of 4p, 9p, and 11q were significant prognostic factors. However, pathologic staging became the only significant factor in a multivariate analysis. CONCLUSIONS CGH not only revealed novel chromosomal aberrations in EC‐SCC, but also found possible genotypic changes associated with disease progression. Despite all of the possible associations of chromosomal aberrations with disease progression, the most important prognostic factor for patients with EC‐SCC was pathologic staging. Cancer 2001;92:2769–77. © 2001 American Cancer Society.