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The biologic basis of fatigue
Author(s) -
Gutstein Howard B.
Publication year - 2001
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20010915)92:6+<1678::aid-cncr1496>3.0.co;2-r
Subject(s) - medicine , cancer , cancer related fatigue , intensive care medicine , mechanism (biology) , epistemology , philosophy
In spite of many remarkable advances in our understanding of the mechanisms of cancer biology, very little attention has been directed toward mechanisms underlying cancer‐induced symptoms. Although fatigue is a widely prevalent complication of cancer, there is a paucity of both basic and clinical research in this area. This article details our current knowledge of mechanisms causing cancer‐related fatigue and briefly discusses currently available therapeutic options. A framework for addressing gaps in our knowledge and recommendations for future research directions are proposed. Cancer 2001;92:1678–83. © 2001 American Cancer Society.