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Surgical treatment for skeletal breast cancer metastases
Author(s) -
Wedin Rikard,
Bauer Henrik C. F.,
Rutqvist LarsErik
Publication year - 2001
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20010715)92:2<257::aid-cncr1317>3.0.co;2-r
Subject(s) - medicine , breast cancer , surgery , pelvis , metastatic carcinoma , population , breast carcinoma , pathologic fracture , orthopedic surgery , neurosurgery , cancer , carcinoma , environmental health
BACKGROUND The objective of this article was to assess the occurrence of symptomatic bone metastases in a defined population of patients with breast carcinoma and to characterize the clinical outcome with reference to surgical treatment for pathologic fracture or neurologic deficit. METHODS The authors identified all patients in the Stockholm Breast Cancer Database (population base 1.8 million) with a diagnosis of bone metastases during 1989–1994. These cases were linked with the Stockholm County Council Hospital Discharge Diagnosis Registry that includes information on in‐patient care and discharge diagnoses. This enabled us to identify patients who had undergone surgical treatment for their bony metastases at any of the six departments of orthopedics in the region, or who had been treated at the one department of neurosurgery. RESULTS Six hundred forty‐one patients with breast carcinoma presented with symptomatic skeletal metastasis during 1989–1994, and 107 (17%) were operated on. Metastases were located in long bones (77), spine (14), and pelvis (6). The median survival postoperatively was 6 months. The total reoperation rate was 0.12. Hip screws and glide‐screw plates were associated more often with failure as was location in the distal femur. Pain decreased postoperatively in 77% of the patients, and function improved in 65%. CONCLUSIONS One in 10 patients with breast carcinoma developed symptomatic bone metastases, and one‐fifth of these patients required surgery for pathologic fracture or neurologic deficit. There was a high failure rate in those hospitals in which few patients were operated on. Cancer 2001;92:257–62. © 2001 American Cancer Society.