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Relation between cyclooxygenase‐2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder
Author(s) -
Shirahama Tsutomu,
Arima Junichirou,
Akiba Suminori,
Sakakura Chohei
Publication year - 2001
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20010701)92:1<188::aid-cncr1308>3.0.co;2-w
Subject(s) - medicine , transitional cell carcinoma , urinary bladder , transitional cell , carcinoma , cyclooxygenase , urinary system , pathology , urology , cancer research , oncology , bladder cancer , cancer , enzyme , biology , biochemistry
BACKGROUND Expression of the inducible form of cyclooxygenase (COX)‐2 is known to correlate with development of transitional cell carcinoma (TCC) of the human urinary bladder. However, the clinical significance of COX‐2 expression with respect to clinicopathologic findings and patient survival is unknown. METHODS COX‐2 expression was examined immunohistochemically in tumor tissues obtained from 108 patients who underwent radical cystectomy for TCCs, without knowledge of clinicopathologic findings. Correlation between COX‐2 expression and clinicopathologic findings and patient survival was determined. RESULTS COX‐2 expression was detected in 34 of 108 (31%) tumors but in none of 10 normal uroepithelial samples. Univariate logistic regression analysis showed a significant correlation between COX‐2 expression and local invasion, infiltration pattern, lymphatic invasion, and venous invasion. However, multivariate logistic regression analysis revealed that only local invasion correlated significantly with COX‐2 expression ( P = 0.047). Cox proportional hazards regression analysis showed that both local invasion ( P = 0.008) and lymph node metastasis ( P = 0.001) were independent prognostic factors; however, COX‐2 expression ( P = 0.16) was not. CONCLUSIONS The authors showed that COX‐2 overexpression plays a role in development and invasion of TCCs, but not prognosis of patients with TCC. COX‐2 inhibitors may be useful for chemoprevention of TCCs and treatment of invasive disease. Cancer 2001;92:188–93. © 2001 American Cancer Society.