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Anti‐Ri–associated paraneoplastic opsoclonus‐ataxia syndrome in a man with transitional cell carcinoma
Author(s) -
Prestigiacomo Charles J.,
Balmaceda Casilda,
Dalmau Josep
Publication year - 2001
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20010415)91:8<1423::aid-cncr1148>3.0.co;2-f
Subject(s) - medicine , opsoclonus , autoantibody , antibody , cancer , transitional cell carcinoma , ataxia , carcinoma , pathology , bladder cancer , small cell carcinoma , antigen , immunology , neuroblastoma , genetics , psychiatry , biology , cell culture
BACKGROUND There are several case reports describing paraneoplastic syndromes in patients with various forms of bladder carcinoma. Current immunologic analyses have enabled the identification of the antineuronal autoantibodies associated with specific syndromes. METHODS A patient with a history of bladder carcinoma presented with opsoclonus and myoclonus. RESULTS Workup confirmed the presence of anti‐Ri antibodies in the patient's serum and cerebrospinal fluid. The target Ri antigen was found to be expressed by the tumor. CONCLUSIONS To the authors' knowledge, there are few reports in the literature describing the long‐term clinical follow‐up and postmortem evaluation in a patient with this form of paraneoplastic syndrome. More important, the authors believe the current study represents the first time that the presence of anti‐Ri antibodies has been noted in a paraneoplastic syndrome associated with transitional cell carcinoma of the bladder. Cancer 2001;91:1423–8. © 2001 American Cancer Society.