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Prognostic factors in patients with locally advanced pancreatic carcinoma receiving chemoradiotherapy
Author(s) -
Ikeda Masafumi,
Okada Shuichi,
Tokuuye Koichi,
Ueno Hideki,
Okusaka Takuji
Publication year - 2001
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20010201)91:3<490::aid-cncr1027>3.0.co;2-l
Subject(s) - medicine , chemoradiotherapy , radiation therapy , oncology , multivariate analysis , proportional hazards model , chemotherapy , performance status , lymph node , carcinoma , survival analysis , gastroenterology , surgery
BACKGROUND The combination of radiation therapy and chemotherapy (chemoradiotherapy [CRT]) has been accepted as standard therapy for patients with locally advanced pancreatic carcinoma (PC). This study investigated prognostic factors in patients with locally advanced PC receiving CRT. METHODS Fifty‐five consecutive patients with locally advanced PC, who received concurrent radiotherapy (50.4 grays) and chemotherapy using 5‐fluorouracil or cisplatin, were analyzed retrospectively to investigate prognostic factors. RESULTS Median survival time and overall survival rates at 1 and 2 years were 301 days, 35.1% and 2.4%, respectively. By multivariate analysis using the Cox proportional hazards model, performance status of 0–1 ( P < 0.01), absence of regional lymph node swelling ( P < 0.01), and serum CA 19‐9 level of less than 1000 ( P = 0.02) were independent favorable prognostic factors. A prognostic index based on the coefficients of those prognostic factors was used to classify patients into three groups with good, intermediate, and poor prognoses. The median survival times for these three groups were 410, 239, and 143 days, respectively ( P < 0.01). CONCLUSIONS The results may be helpful in predicting life expectancy, determining treatment strategies, and designing future clinical trials. Cancer 2001;91:490–5. © 2001 American Cancer Society.