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CYFRA 21‐1 determination in patients with esophageal squamous cell carcinoma
Author(s) -
Kawaguchi Hidetoshi,
Ohno Shinji,
Miyazaki Mitsuhiro,
Hashimoto Kenkichi,
Egashira Akinori,
Saeki Hiroshi,
Watanabe Masayuki,
Sugimachi Keizo
Publication year - 2000
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20001001)89:7<1413::aid-cncr1>3.0.co;2-i
Subject(s) - medicine , esophageal squamous cell carcinoma , basal cell , carcinoma , oncology , dermatology , gastroenterology , pathology
BACKGROUND While there are reports that CYFRA 21‐1 is a useful tumor marker, to our knowledge the clinical utility of this marker to detect recurrences for squamous cell carcinoma of the esophagus has not been addressed. METHODS By immunoradiometric assay, human serum levels of CYFRA 21‐1, SCC antigen and CEA were measured in esophageal squamous cell carcinoma patients prior to their initial treatment. Monthly follow‐ups of these tumor markers was done after surgery. RESULTS The diagnostic sensitivity of CYFRA 21‐1 was 43.9% (18 of 41), a value superior to that for SCC antigen (26.8%) and CEA (17.0%) ( P < 0.05). The positive rates of CYFRA 21‐1 increased with progression of the disease, 22.2% of pTNM Stage 0‐IIA and 77.8% of pTNM Stage IIB/III ( P = 0.013), whereas SCC antigen and CEA rates were not related to pTNM stage. Among 13 patients with clinical evidence of a recurrence, 76.9% (10 of 13) exhibited an increase in CYFRA 21‐1, and this increase was evident before clinical detection of the recurrence in 9 of these 13 patients (69.2%). Consequently, postoperative elevations of serum CYFRA 21‐1 levels were indicative of a tumor recurrence 1–13 months before acquisition of clinical and radiological data. CONCLUSIONS The assay of CYFRA 21‐1 is useful not only for diagnosis but also for close monitoring of patients with esophageal squamous cell carcinoma. Cancer 2000;89:1413–7. © 2000 American Cancer Society.