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Trends in incidence and management of gallbladder carcinoma
Author(s) -
Manfredi Sylvain,
Benhamiche Anne Marie,
Isambert Nicolas,
Prost Patricia,
Jouve Jean Louis,
Faivre Jean
Publication year - 2000
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20000815)89:4<757::aid-cncr6>3.0.co;2-h
Subject(s) - medicine , gallbladder , incidence (geometry) , relative survival , population , carcinoma , relative risk , stage (stratigraphy) , multivariate analysis , gastroenterology , surgery , epidemiology , confidence interval , cancer registry , paleontology , physics , environmental health , optics , biology
BACKGROUND Little is known, at a population level, about the incidence and management of gallbladder carcinoma. The objective of this study was to determine trends in incidence, treatment, stage at diagnosis, and prognosis of gallbladder carcinoma in a well defined population. METHODS A series of 484 patients diagnosed over a 20‐year period (1976–1995) in a French well defined population was used. Incidence rates were calculated by gender, age groups, and 5‐year periods. Prognosis was determined using crude and relative survival rates. A multivariate relative survival analysis was performed. RESULTS Age‐standardized incidence rates were 0.8 per 100,000 inhabitants for men and 1.5 per 100,000 inhabitants for women. There were no significant time trends in incidence in both genders. The proportion of cases resected for cure increased from 18.1% (1976–1980) to 42.4% (1991–1995) ( P < 0.001) as well as the proportion of cases limited to the gallbladder wall, respectively from 15.7% to 27.8% ( P < 0.001). Relative survival rates were 16.6% at 1 year and 6.2% at 5 years. Age, stage at diagnosis, and period of diagnosis significantly influenced the prognosis of gallbladder carcinoma. The 5‐year relative survival rate rose from 2.7% (1976–1985) to 10.2% (1986–1995). The multivariate analysis showed that age and stage at diagnosis were independent prognostic factors. CONCLUSIONS This study demonstrated that gallbladder carcinoma incidence is stable in France and that substantial advances in its management have been achieved, but there is evidence that further improvements are necessary to increase survival. Cancer 2000;89:757–62. © 2000 American Cancer Society.