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Decreased expression of CD44, alpha‐catenin, and deleted colon carcinoma and altered expression of beta‐catenin in ulcerative colitis‐associated dysplasia and carcinoma, as compared with sporadic colon neoplasms
Author(s) -
Mikami Tetuo,
Mitomi Hiroyuki,
Hara Atsuko,
Yanagisawa Nobuyuki,
Yoshida Tsutomu,
Tsuruta Osamu,
Okayasu Isao
Publication year - 2000
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(20000815)89:4<733::aid-cncr3>3.0.co;2-#
Subject(s) - ulcerative colitis , medicine , dysplasia , cd44 , carcinoma , catenin , beta catenin , alpha (finance) , colorectal cancer , beta (programming language) , pathology , cancer research , cancer , gene , cell , disease , biology , wnt signaling pathway , surgery , biochemistry , genetics , construct validity , computer science , patient satisfaction , programming language
BACKGROUND To clarify the cell adhesion status in ulcerative colitis (UC)–associated colon neoplasm, expression of cell adhesion molecules were investigated and compared with that of sporadic colon neoplasm. METHODS A total of 14 low grade dysplasias, 16 high grade dysplasias, and 8 adenocarcinomas associated with UC and 17 sporadic adenomas with mild to moderate dysplasia, 22 adenomas with severe dysplasia, and 15 invasive adenocarcinomas were immunohistochemically examined using monoclonal antibodies against CD44, E‐cadherin, alpha‐ and beta‐catenin, and deleted colon carcinoma (DCC). RESULTS CD44, especially its standard form, and DCC expression was stronger in the sporadic colon neoplasms than in the UC‐associated lesions. Although E‐cadherin did not show significant differences between the two cases, alpha‐catenin was more expressed in sporadic colon adenomas with severe dysplasia and carcinomas than in their UC‐associated counterparts. Membranous beta‐catenin staining was stronger in UC‐associated neoplasms, whereas sporadic lesions had greater cytoplasmic and nuclear expression. CONCLUSIONS The differences in cell adhesion molecule expression suggests that UC‐associated and sporadic colon neoplasms arise from different pathways of tumorigenesis. Cancer 2000;89:733–40. © 2000 American Cancer Society.